GameGuide

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General Tips
When given an opportunity to power up between missions or at Divinity Statues, it is very important for you to give Nero Streak and Split early on, because both are very useful moves. Streak in particular comes in handy in lots of situations.
Air Hike (in the abilities section of the Power Up menu) is necessary for many secret areas in the game, such as secret red orb locations and blue orb fragments, so it should be given a high priority in Power Up menus.
In general (these are general tips, after all) Nero’s gun is too weak to be efficient or useful, while Dante’s various guns are strong enough to be helpful.
For Nero, you typically use slashes primarily to take away enemy health with Busters (O button) mixed in, which deal more damage. Keeping a good mix of these methods and using varying sword attacks all the time gives you a better Stylish level, which helps give you more Proud Souls to upgrade.
If a boss ever appears to be slumped over or dazed, that typically means you can perform a special Buster attack on them to cause major damage
Devil May Cry 4 Walkthrough